姓名：李图帅

职称：副教授

电子邮箱：litushuai@cslg.edu.cn

研究方向：创新型药物药理毒理学

个人简介

博士研究生、硕导，民建会员。2020年博士毕业于南京大学药学院，先后承担国家级、省级、市厅级项目5项，近五年参与发表SCI论文20篇，其中以第一作者及通讯作者发17篇，申请发明专利4项。

主要科研项目

1.国家自然科学基金青年项目，82404992，20250101-20271231，30万，主持，在研；

2.江苏省产学研合作项目，BY20251560，202512-202612，30万元，主持，在研；

3.省自然科学基金青年项目，BK20221091，202207-202407，20万，主持，已结题；

4.中国博士后科学基金第71批面上项目，2022M711369，202207-202407，8万，主持，已结题；

5.无锡市科技局项目。20210843，202107-202306，10万，主持，已结题。

近期代表性论文

1. Li T S#, Sun W X, Qian D, Wang P, Liu X Y, He C S, Chang T, Liao G F, Zhang J*. Plant-derived biomass-based hydrogels for biomedical applications[J]. Trends in Biotechnology, 2025, 43(4): 802-811. First author，中科院一区，IF=17.299

2. Zhang J#, Sun W X, Wu W D, Qin Z H, Wei B, Li T S*. METTL3-dependent m6A methylation of circCEACAM5 fuels pancreatic cancer progression through DKC1 activation[J]. Cellular and Molecular Life Sciences, 2025, 82(1): 132. Corresponding author,中科院二区，IF=6.2001

3.Tushuai Li#, Wenxue Sun, Da Qian, Ruilong Jia, Xingyu Liu, Chengsheng He, Tong Chang, Guangfu Liao, Jie Zhang*. Plant-derived biomass-based hydrogels for biomedical applications[J]. Trends in biotechnology. 2024, S0167-7799(24): 00254-3. First author,中科院一区, IF=17.2996

4.Tushuai Li#, Renjie Gao, Kaiwen Xu, Pengpeng Pan, Congcong Chen, Daokuan Wang, Keyi Zhang, Jilei Qiao, Yue Gu. BCL7A inhibits the progression and drug-resistance in acute myeloid leukemia. Drug Resistance Updates. 2024, 76: 101120. First author,中科院一区, IF=24.3008

5.Tushuai Li#, Wenxue Sun, Shenglong Zhu, Yue Gu, Lisha Yu, Jie Zhang*, Yongquan Chen*. T-2 Toxin-mediated β-Arrestin-1 O-GlcNAcylation exacerbates glomerular podocyte injury via regulating histone acetylation [J]. Advanced Science. 2024, 11(7): 2307648. First author,中科院一区, IF=15.100

6.Tushuai Li#, Longjiang Xu, Zhe Wei, Shaomei Zhang, Xingyu Liu, Yanzi Yang*, Yue Gu*, Jie Zhang*. ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma [J]. Molecular Cancer. 2023, 22(1):184. First author,中科院一区, IF=41.44.

7.Tushuai Li#, Yue Gu, Baocai Xu, Kamil Kuca, Jie Zhang, Wenda Wu*. CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure [J]. Molecular Cancer. 2023, 22(1):77. First author , 中科院一区, IF=41.44.

8.Fang Lei#, Li TuShuai#, Zhang JingZi#, Liu ZhiHong, Yang Jie, Wang BingHao, Wang YuMeng, Zhou Jie, Kong LingDong*. Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation [J]. Signal Transduction and Targeted Therapy, 2021, 6(1): 253. First author, 中科院一区, IF= 40.800.

9.Jie Zhang#, Shuang Yang, Baocai Xu, Zihui Qin, Xinyi Guo, Ben Wei, Qinghua Wu, Kamil Kuca, Tushuai Li*, Wenda Wu*. Foodhorne toxin Aflatoxin B induced glomerular podocyte inflammation through proteolysis of RelA, dowmregulation of mi-9 and CXCR4/TXNIP/NIRP3 pathway [J]. Food Science and Human Wellness, 2024, 13(4): 2289-2309. Co-corresponding author, 中科院一区, IF= 8.0216.

10.Jie Zhang#, Yue Gu, Wenxue Sun, Lisha Yu, Tushuai Li*. Tetrahydrocurcumin protects against GSK3β/PTEN/PI3K/Akt-mediated neuroinflammatory responses and microglial polarization following traumatic brain injury[J]. Molecular Neurobiology, 2024,61(9):7026-7036. Corresponding author, 中科院二区, IF=5.100.

11.Tushuai Li#, Yue Gu, Lisha Yu, Shenglong Zhu, Jie Zhang, Yongquan Chen. Stimuli-responsive double single-atom catalysts for parallel catalytic therapy[J]. Pharmaceutics. 2023,15(4):1217. First author, 中科院二区, IF= 6.5245.

12.Tushuai Li#, Chen Li, Fu Xiao, Liu Zhihong, Zhu Shenglong, Chen Yongquan, Zhang Jie*. Iron Single-Atom nanocatalysts in response to tumor microenvironment for highly efficient Chemo-chemodynamic therapy. Journal of Industrial and Engineering Chemistry, 2022, 112:210-217. First author, 中科院二区, IF= 6.7598.

13.Tushuai Li#, Zhihong Liu, Xiao Fu, Yongquan Chen, Shenglong Zhu, Jie Zhang *. Co-delivery of Interleukin-12 and doxorubicin loaded Nano-delivery system for enhanced immunotherapy with polarization toward M1-type Macrophages. European Journal of Pharmaceutics and Biopharmaceutics, 2022,177:175-183. First author, 中科院二区, IF= 5.5886.

14.Tushuai Li#, Chen Li, Wang ShanChun, Yang YanZi, Xu HongJiang, Gu HongMei, Zhao XiaoJuan, Dong Ping, Pan Ying, Shang ZhanQiang, Zhang XiQquan, Kong LingDong*. Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1. Biochemical Pharmacology, 2019,166:139-152. First author, 中科院二区, IF=6.1004

15.Pei JiaPing#, Dou Hui, Liu ChenCai, Li TuShuai*. Manganese single-atom nanostructures for highly efficient tumor therapy. Journal of Industrial and Engineering Chemistry. 2022, 109:330-337. Corresponding author, 中科院二区, IF=6.7598.

16.Zhang Jie#, Liu Xuerun, Su Ying, Li TuShuai*. An update on T2-toxins: metabolism, immunotoxicity mechanism and human assessment exposure of intestinal microbiota. Heliyon. 2022,8(8):e10012. Corresponding author, 中科院四区, IF= 3.7760.

17.Zhang Na#, Zhang Jie, Liu Zhihong, Li TuShuai*. Identification of signaling pathways associated with achaete-scute homolog 1 in glioblastomas through ChIP-seq data bioinformatics. Frontiers in Genetics, 2022, 13: 938712. Corresponding author, 中科院三区, IF= 4.7722.

18.Jie Zhang, Tushuai Li#, Qinghua Wu, Zihui Qin, Ben Wei, Ran Wu, Xinyi Guo, Huiping Xiao, Wenda Wu. Emetic response to T-2 Toxin correspond to secretion of glucagon-like peptide-17-36 amide and glucose-dependent insulinotropic polypeptide. Toxins. 2022,14(6):389. Second author,中科院二区, IF= 5.0751.

19.WenYuan Wu, ZiXuan Wang, Tushuai Li#, XiaoQin Ding, ZhiHong Liu, Jie Yang, Lei Fang, LingDong Kong. SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway. Redox Biology. 2022,52:102303. Third author, 中科院一区, IF= 10.7865.

20.Xuan Jiang, Siyu Ji, Fenglai Yuan, Tushuai Li#, Siyuan Cui, Wei Wang, Xianlong Ye, Rong Wang, Yongquan Chen, Shenglong Zhu. Pyruvate dehydrogenase B regulates myogenic differentiation via the FoxP1-Arih2 axis. Journal of Cachexia Sarcopenia and Muscle. 2023,14(1):606-621.中科院一区, IF= 12.0626.

专利

1.吴文达; 张杰; 李图帅; 徐宝才; 秦子慧; 乐建铭; 张华月; マウス腸管オルガノイドを腸内分泌細胞に指向性分化するように誘導する培地及びその使用，2024-07-24至, 日本，特願２０２３－１７９７１８.

2.吴文达、徐宝才、秦子慧、张杰、李图帅、孟笑杰；miR-9及其类似物在制备诊断和/或治疗细胞炎症的药物中的应用, 2024-5-27, 中国，202310730348.5.

作品获奖

1.苏州市自然科学论文二等奖，2024年。

主要承担的教学课程

1.细胞工程与实验

2.AI药物分子设计

3.高级生物化学