姓名：杨锐

职称：讲师

电子邮箱：yangruithrive@163.com

研究方向：生物光电功能材料的应用；

有机小分子荧光探针在诊断及治疗中的应用

个人简介

杨锐，男，中共党员，博士，讲师，现为苏州工学院电子信息工程学院教师。2012.9-2016.6就读于济南大学, 获得工学学士学位；2016.09-2021.06 就读于山东大学晶体材料研究院全国重点实验室，获得工学博士学位。2021年7月加入苏州工学院电子信息工程学院光电信息科学与工程专业。主要科研方向为光电功能材料的制备及性能研究，近年来以第一作者发表SCI论文多篇。

主要科研项目

1. 国家自然科学基金委员会, 面上项目, 52073163, 能够实时长程追踪线粒体的长烷基链非反应型荧光探针, 2021-01-01 至 2024-12-31，59万元，在研，参与。

2. 山东省自然科学基金委员会，重大项目，ZR2017ZC0227，基于荧光分子探针与光学切片成像的肿瘤病理快速诊断技术， 2017-08-01至2019-07-31，150万元，结题，参与

近期代表性论文

1. Wei, Mengmeng; Zhang, Yuxuan; Qiang, Wuyou; Liu, Jiawei; Qian, Yi; Xu, Jing; Tang, Xiaoyan; Liu, Jiaojiao; Wang, Shenqiang; Jiang, Tingwang; Hong, Xuekun**; Yang, Xifeng*; Yang, Rui***; Harnessing a MMP-sensitive fluorescent probe for in-situ and reversible monitoring MMP alteration in dual color based on aggregation/monomer mechanism, Analytica Chimica Acta, 2026, 1417, 345797.

2. Wei, Mengmeng⁎; Xiang, Derong; Zhang, Yuxuan; Qiang, Wuyou; Liu, Jiawei; Xu, Jing; Tang, Xiaoyan; Zhang, Qijian*; Han, Zhida**; Yang, Xifeng***; Yang, Rui****; Mitochondria to nucleus/nucleolus migration probe for in-situ and dual-color visualization of MMP alteration and monitoring apoptosis, Analytica Chimica Acta, 2026, 1386, 345040.

3. Yang, Rui⁎; Yao, Xuechen; Tang, Xiaoyan; Liu, Ying; Yang, Xifeng; Ma, Haixia; Kuang, Yawei; Jiang, Tingwang*; Qiao, Jia-Wei*; Wei, Mengmeng*; Mitochondrion-immobilized fluorescent probe for in-situ tracking and visualization of mitophagy with long-term and monitoring liver injury, Sensors and Actuators: B. Chemical, 2025, 436, 137684.

4. Yang, Rui⁎; Zhu, Changxin; Yang, Xifeng; Kuang, Yawei; Jiang, Tingwang⁎; Wang, Shenqiang⁎; Wei, Mengmeng⁎; Simultaneous dual-color visualization of lysosome, mitochondria, nucleoli and monitoring apoptosis with a single fluorescent probe, Sensors and Actuators: B. Chemical, 2025, 424: 136912.

5. Yang, Rui⁎; Lu, Xue; Gao, Qinyi; Hu, Jiashuo; Yao, Xuechen; Yu, Fangyuan; Yang, Xifeng; Liu, Yushen⁎; Wang, Shenqiang⁎; Wei, Mengmeng⁎; Simultaneous and discriminative visualization of endoplasmic reticulum and lysosomes in apoptosis and autophagy using a single fluorescent probe, Sensors and Actuators: B. Chemical, 2025, 425: 136981.

6. Yang, Rui⁎; Gao, Qinyi; Lu, Xue; Wu, Yukun; Changxin Zhu; Zhida Han⁎; Li, Chuanya⁎; Wei, Mengmeng⁎; Wash-free and ultra-low concentration monitor lysosomal viscosity in apoptosis with a noteworthy fluorescent probe, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 329, 125481.

7. Wei, Mengmeng⁎; Hu, Jiashuo; Yu, Fangyuan; Yao, Xuechen; Zeng , Zhongming; Liu,Yushen⁎; Yang, Rui⁎; Wei Qin⁎; NIR (II) photothermal imaging and amplifying photothermal effect through magnetic field in organic cocrystals, Chemical Engineering Journal, 2025, 508, 161089.

8. Yang, Rui⁎; He, Wei; Zhu, Changxin; Yang, Xifeng Kuang, Yawei; Zhu, Tao; Xu, Jingyang; Zhao, Yuang; Jiang, Tingwang⁎; Liu, Yushen⁎; Wei, Mengmeng⁎; Exquisite visualization of mitophagy and monitoring the increase of lysosomal micro-viscosity in mitophagy with an unusual pH-independent lysosomal rotor, Analytica Chimica Acta, 2024, 1302: 342506.

9. Yang, Rui⁎; Zhu, Tao; Xu, Jingyang; Zhao, Yuang; Kuang, Yawei; Sun, Mengni; Chen, Yuqi; He, Wei; Wang, Zixing; Jiang, Tingwang⁎; Zhang, Huiguo⁎; Wei, Mengmeng⁎; Organic Fluorescent Probes for Monitoring Micro-Environments in Living Cells and Tissues, Molecules, 2023, 28(8): 3455.

10. Yang, Rui; Meng, Fangfang⁎; Niu, Guangle; Niu, Jie; Hao, Qiuhua; Zong, Chong; Gao, Peng⁎; Yu, Xiaoqiang⁎; Long-term tracking of endoplasmic reticulum autophagy by a fluorescent probe with a long alkyl chain, Sensors and Actuators: B. Chemical, 2022, 372: 132639.

11. Li, Hui; Li, Fei; Liu, Fang; Chen, Xiao; Xu, Wenyuan; Shen, Liang; Xu, Jingkun*, Yang, Rui* and Zhang, Ge*; High-Quality Conjugated Polymers Achieving Ultra-Trace Detection of Cr2O72- in Agricultural Products, Molecules, 2022, 27, 4294.

12. Yang, Rui; He, Xiuquan; Niu, Guangle⁎; Meng, Fangfang; Lu, Qing; Liu, Zhiqiang⁎; Yu, Xiaoqiang⁎; A Single Fluorescent pH Probe for Simultaneous Two-Color Visualization of Nuclei and Mitochondria and Monitoring Cell Apoptosis, ACS Sensors, 2021, 6 (4): 1552-1559. 封面论文

13. Yang, Rui; Hao, Qiuhua; Lu, Qing; Meng, Fangfang; Niu, Jie; Liu, Zhiqiang; Niu, Guangle; Yu, Xiaoqiang; Fabrication of small-structure red-emissive fluorescent probes for plasma membrane enables quantification of nuclear to cytoplasmic ratio in live cells and tissues, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 249: 119338.

14. Zhang, Huamiao; Tian, Minggang; Yang, Rui; He, Xiuquan; Yu, Xiaoqiang ; A general strategy to increase emission shift of two-photon ratiometric pH probes using a reversible intramolecular reaction of spiro-oxazolidine, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 246: 0-119035.

15. Meng, Fangfang; Niu, Jie; Zhang, Huamiao; Yang,Rui; Lu, Qing; Niu, Guangle; Liu, Zhiqiang; Yu, Xiaoqiang; A pH-Sensitive Spirocyclization Strategy for Constructing a Single Fluorescent Probe Simultaneous Two-Color Visualizing of Lipid Droplets and Lysosomes and Monitoring of Lipophagy, Analytical Chemistry, 2021, 93(34): 11729-11735.

专利

1.于晓强; 杨锐; 牛广乐; 何秀全; 一种能双色同时成像细胞核和线粒体的pH敏感型荧光探针,中国, 202011247064.3.

2.杨锐；魏蒙蒙；刘玉申；况亚伟；王书昶；一种溶酶体荧光探针、其制备方法及应用，中国，202111263710.X.

3.杨锐;蒋廷旺;刘玉申;况亚伟;郝明辉;魏蒙蒙；一种荧光探针的用途，中国，202111249302.9.

4.杨锐; 蒋廷旺; 魏蒙蒙; 张惠国; 刘玉申; 钱斌; 韩志达; 况亚伟; 一种荧光探针、其制备方法及应用,中国，202211482263.1.

主要承担的教学课程

1.《激光原理与技术》

2. 《光电子技术实验》

3.《科学与工程制图》